Proliferation of SDDS Support for Various Platforms and Languages

Since Self-Describing Data Sets (SDDS) were first introduced, the source code has been ported to many different operating systems and various languages. SDDS is now available in C, Tcl, Java, Fortran, and Python. All of these versions are supported on Solaris, Linux, and Windows. The C version of SDDS is also supported on VxWorks. With the recent addition of the Java port, SDDS can now be deployed on virtually any operating system. Due to this proliferation, SDDS files serve to link not only a collection of C programs, but programs and scripts in many languages on different operating systems. The platform independent binary feature of SDDS also facilitates portability among operating systems. This paper presents an overview of various benefits of SDDS platform interoperability.Comment: 3 pages, 2 figures, submitted to ICALEPCS 200

Mössbauer study of colossal magnetoresistive La[sub 1-x]Sr[sub x]Mn[sub 0.9]Fe[sub .1]O[sub 3] (x=0,0.1,0.2,0.3)

Includes bibliographical references (pages [61]-62)The Mössbauer effect is a phenomenon that makes it possible to study local magnetic and electric interactions. General concepts along with computational methods are introduced in the theoretical part of this thesis. Mössbauer studies have been conducted on ^57Fe doped colossal magnetoresistive rare-earth transition metal oxides. Temperature dependent Mössbauer effect, magnetization and resistivity measurements have been made for La[sub 1-x]Sr[sub x]Mn[sub 0.9]Fe[sub .1]O[sub 3] (x=0,0.1,0.2,0.3). Various techniques of synthesis (air, Ar, quenching, slow cooling) were used to create compounds that are virtually free of defects. The 57Fe was shown to have a valence state of 3+ from the Mössbauer effect measurements. As x increases, the crystal structure changes from monoclinic to orthorhombic to rhombohedral, and the transport properties change from antiferromagnetic-semiconductor to ferromagnetic-semiconductor to ferromagnetic-colossal magnetoresistive metal. The Mössbauer effect shows broader distributions of magnetic fields below the magnetic ordering temperature as x is increased. The experimental results are discussed in terms of local structure and time-dependent magnetic exchange interactions.M.S. (Master of Science

Real World Clinical Utility of Neurophysiological Measurement Utilizing Closed-Loop Spinal Cord Stimulation in a Chronic Pain Population: The ECAP Study Protocol.

BACKGROUND: Spinal cord stimulation (SCS) is an established chronic pain treatment, but the effectiveness of traditional, open-loop paradigms has been plagued by variable sustainability in a real-world setting. A new approach, utilizing evoked compound action potential (ECAP) controlled closed-loop (CL) SCS, continuously monitors spinal cord activation and automatically adjusts the stimulation amplitude of every pulse, maintaining stimulation at the prescribed ECAP level through this continual feedback mechanism. Recent studies demonstrated the long-term safety and efficacy of ECAP-controlled CL-SCS. Here, we report the design of a prospective, multicenter, single-arm feasibility study to characterize clinical outcomes in a real-world chronic pain population utilizing ECAP-controlled CL-SCS. Objective neurophysiological measurements such as device performance and patient therapy compliance, will be analyzed against baseline biopsychosocial assessments, to explore the clinical utility of these objective physiologic biomarkers in patient phenotyping. METHODS: This study will enroll up to 300 subjects with chronic, intractable trunk and/or limb pain in up to 25 United States investigation sites. Subjects meeting eligibility criteria will undergo a trial procedure and a permanent implant following a successful trial. Neurophysiological measurements (measured in-clinic and continuously during home use) and clinical outcomes including pain, quality-of-life, psychological, emotional, and functional assessments will be collected at baseline, trial end, and up to 24-months post-implantation. DISCUSSION: Associations between objective neurophysiological data, clinical evaluation and patient-reported outcomes may have important clinical and scientific implications. They may provide novel insights about the chronic pain pathophysiology, its modulation during CL-SCS, and identification of pain phenotypes and/or mechanisms associated with treatment response during SCS trials and long-term therapy. Data from the ECAP study could lead to improvements in diagnosis, assessment, patient identification and management of chronic pain. It could also provide the foundation for development of a new SCS treatment approach customized by the patients pain phenotype, unique neurophysiology, and disease severity

Self-amplified spontaneous emission saturation at the Advanced Photon Source free-electron laser (abstract) (invited)

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